CIR Safety Review: The CIR Expert Panel noted that studies indicated that Squalane was slowly absorbed through the skin, and both Squalane and Squalene were poorly absorbed from the gastrointestinal tract. The toxicity of these two ingredients by all routes was low. At 100% concentrations, both compounds were nonirritants to the skin and eyes. Products containing Squalene were not dermal irritants or sensitizers.

Squalane and Squalene may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Directive of the European Union.
Link to the EU Cosmetics Directive: http://ec.europa.eu/consumers/sectors/cosmetics/documents/di...

Squalene is a branched-chain hydrocarbon with six carbon-carbon double bonds. Squalane is a saturated branched chain hydrocarbon (fully hydrogenated). Both ingredients function as hair conditioning and skin conditioning agents in cosmetics and personal care products.