Botanical and botanically derived ingredients used in the formulation of cosmetics are generally mild and safe. Prior to marketing the finished cosmetic product, the safety of each ingredient must be substantiated in accordance with 21 CFR 740.10. Safety substantiation of cosmetic ingredients may include tests for ocular and skin irritation as well as allergenicity, phototoxicity, photoallergenicity and mutagenicity, depending on the application or intended use. There is a considerable body of information about the safety of botanical ingredients and a well-established history of use. These resources are consulted to ensure the safety of these materials as they are used in cosmetics.

Aesculus Hippocastanum (Horse Chestnut) Seed Extract may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European Union.

In selecting plant-derived ingredients for cosmetics and personal care products, formulators rely on the extensive history of their preparation and use. Such materials have been used for a long time and, based upon this experience, extensive knowledge of their safety has been gained. In the situation of newly identified botanicals in the cosmetic industry, appropriate ocular and skin safety studies are conducted prior to release into general commerce. There are many different references that describe the isolation, use and safety of botanical preparations.

More information about botanicals.