Squalene and Squalane
Safety Information
Expert Panel for Cosmetic Ingredient Safety
The Expert Panel for Cosmetic Ingredient Safety (Expert Panel) first reviewed the safety of squalene and squalane in 1982, concluding both were safe as cosmetic ingredients in what was then present practices of use and concentration.
The Expert Panel reviewed safety data and uses again in 2001 and 2019 reaffirming the original conclusion that squalane and squalene are safe as cosmetic ingredients in the present practices of use and concentration.
Squalane is listed on the EU’s Cosmetic Ingredient Inventory (CosIng) and may be used without restrictions in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European UnionUnder the general provisions of the cosmetics regulation of the EU, ingredients appearing on the following function-specific annexes must comply with the listed restrictions and/or specifications: colorants (Annex IV), preservatives (Annex V), UV filters (Annex VI) and other ingredients with specific concentration limits and/or other restrictions (Annex III). Ingredients specifically prohibited from use in cosmetic products are listed in Annex II. Other ingredients listed in the EU cosmetic ingredient database (CosIng) may be used without restrictions..
Squalene is listed in the EU’s Annex II, specifically under entry 419, which designates substances that are prohibited from use in cosmetic products.